Vitenskapelige artikler
Norske og internasjonale studier på effekten av plantesteroler på serum kolesterol
| Forfatter, år | Beskrivelse av studien | Hovedresultat |
| Katan et al. 2003 |
Meta-analyse av 41 kliniske studier. |
LDL: -10% |
| Hendriks et al. 2003 | Friske, t-kol<8 mmol/l Randomisert, dobbeltblindet placebo- kontrollert studie. N=185, 1år, 20g/dag (1,6 gPS) |
LDL: -6% T-kol: -4% |
| Amundsen et al. 2002 | Barn med familiær hyperkolesterolemi Dobbelt-blindet, placebo-kontrollert. 8 uker, 18 g/dag (1,6 g PS) |
LDL: -10% T-kol: -7% |
| De Jongh et al. 2003 | Barn med familiær hyperkolesterolemi Dobbelt-blindet, placebo-kontrollert. 4 uker, 15 g/dag (2,3 g PS) |
LDL: -14% T-kol: -11% |
| Neil et al. 2001 | Dobbelt-blindet, placebokontrollert Halvparten statinbehandling, den andre halvparten type IIa hyperkolesterolemi uten medisinsk behandling 8 uker, 25g/dag (2,5 g PS) |
LDL: - 10-15% Ingen forskjell i respons mellom de som hadde/ikke hadde statin behandling. Effekten av plantesteroler er additiv til effekten av statiner. |
| Simons et al. 2002 | Personer med primær hyperkolesterolemi Multi-senter, dobbelt-blindet, placebo-kontrollert. 4uker, 25g/dag (2 g PS) Kombinasjon med statinbehandling. |
LDL: • Statinbeh: -32% • PS: -8% • Statinbeh + PS: -39% Additiv effekt tilsvarende dobling av statindosen. |
Forkortelser: T-kol:serum totalkolesterol, PS:plantesteroler, LDL-kol:serum LDL-kolesterol
Relevante referanser på plantesteroler og serum kolesterol:
- Cerqueira MT, Fry MM, Connor WE. The food and nutrient intakes of the Tarahumara Indians of Mexico. Am J Clin Nutr. 1979;32(4):905-15.
- Colgan HA, Floyd S, Noone EJ, Gibney MJ, Roche HM. Increased intake of fruit and vegetables and a low-fat diet, with and without low-fat plant sterol-enriched spread consumption: effects on plasma lipoprotein and carotenoid metabolism. J Hum Nutr Diet. 2004;17(6):561-9
- Hirai K, Shimazu C, Takezoe R, Ozeki Y. Cholesterol, phytosterol and polyunsaturated fatty acid levels in 1982 and 1957 Japanese diets. J Nutr Sci Vitaminol (Tokyo). 1986;32(4):363-72.
- Jones PJ, Raeini-Sarjaz M, Ntanios FY, Vanstone CA, Feng JY, Parsons WE. Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J Lipid Res. 2000;41(5):697-705.
- Kwiterovich PO Jr, Chen SC, Virgil DG, Schweitzer A, Arnold DR, Kratz LE. Response of obligate heterozygotes for phytosterolemia to a low-fat diet and to a plant sterol ester dietary challenge. J Lipid Res. 2003;44(6):1143-55.
- Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ. 1994;308(6925):367-72.
- Müller H, Kirkhus B, Pedersen JI. Serum cholesterol predictive equations with special emphasis on saturated and trans fatty acids. An analysis from designed controlled studies. Lipids, 2001; 36 (8): 783-791.
- Noakes M, Clifton P, Ntanios F, Shrapnel W, Record I, McInerney J. An increase in dietary carotenoids when consuming plant sterols or stanols is effective in maintaining plasma carotenoid concentrations. Am J Clin Nutr. 2002;75(1):79-86.
- Pedersen JI, Kirkhus B, Müller H. Serum cholesterol predictive equations in product development. European Journal of medical Research 2003; 8: 325-331.
- Tonstad S, Strøm E, Bergei Schreiber C, Ose L. Serum cholesterol response to replacing butter with a new trans-free margarine. Nutrition, Metabolism and Cardiovascular diseases 2001; 11: 320-326.
- Vuoristo M, Miettinen TA. Absorption, metabolism, and serum concentrations of cholesterol in vegetarians: effects of cholesterol feeding. Am J Clin Nutr. 1994;59(6):1325-31.
Forkortelser: T-kol:serum totalkolesterol, PS:plantesteroler, LDL-kol:serum LDL-kolesterol
